Bioactive Natural Products: Detection, Isolation, and Structural Determination, 2nd ed. Steven Colegate, Russell J. Molyneux, eds., 2007.
A unique format that allows readers to tailor each isolation method to specific problems. Includes how-to chapters on bioactivity-directed isolation and characterization of natural products. Examines the search for bioactive components from specific biological sources, including endophytes, chicken ova, and myxobacteria. Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. Hardcover, 624 pp. B551
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