New cell line lets researchers use CRISPR to reversibly switch off genes

‘CRISPR interference,’ or CRISPRi, enables study of basic cell biology and disease in human stem cells. The technique’s co-creator, UCSF’s Martin Kampmann, has teamed up with the Allen Institute for Cell Science to release a CRISPRi stem cell line for any researcher to use.

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Stories

Projects launch to map the nucleus, the information center of our cells

Through the NIH-funded 4D Nucleome program, new efforts are underway to model the nucleus in human stem cells and capture 3D genome organization in mouse and human brain cells.

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Open Science Week | Supporting education and research

In September, we launched Open Science Week, a campaign to celebrate and promote the value of open science. We asked college science teachers to share how they are using resources from the Allen Institute to help remote education during the COVID-19 pandemic for a news article; and Cell Science advisor Jennifer Lippincott-Schwartz shared her views on the importance of open science in a video.

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Cell Bio 2020

Are you participating in this year’s Cell Bio Virtual 2020 Online ASCB | EMBO Conference? See Allen Institute for Cell Science presentations, keep up with us on social media @alleninstitute (#cellbio2020), join us at our Round Table Discussion, and view our posters.

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2020 Seattle Cell Science Symposium

This year’s Seattle Cell Science Symposium will convene virtually Dec. 17-18. Join us online 8:30am-12:30pm PT each day for a series of talks showcasing research in the cell biology community and the Allen Institute for Cell Science.

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New cell lines and plasmids available

In addition to the CRISPRi stem cell line, our researchers also released a cardiac and skeletal muscle-specific line that tags dystrophin with mEGFP, and two new donor plasmids used to create the mEGFP-tagged dystrophin cell line and mEGFP-tagged mitochondrial transcription factor A (TFAM) cell line, which labels mitochondrial nucleoids.

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